蘇教授從事骨科臨床工作 20 余年，主要致力于頸椎病，腰椎間盤突出癥，青少年特發(fā)性脊柱側(cè)凸、遺傳性骨骼畸形等常見運動系統(tǒng)疾病的機制與臨床診治相關(guān)研究，同時擅長常規(guī)頸椎病/腰椎病的最優(yōu)化治療，擅長脊柱截骨矯形術(shù)、脊柱腫瘤完整切除、后路寰樞椎椎弓根釘固定及植骨融合術(shù)。2015年曾接診一名嚴重神經(jīng)肌肉性脊柱側(cè)凸合并呼吸功能受限，用力肺活量（FVC）僅為18%，屬于手術(shù)的絕對禁忌癥。此例患者為我國首例，蘇教授經(jīng)過術(shù)前頭環(huán)牽引及呼吸鍛煉的方法，為患者施行了手術(shù)，使患者的側(cè)凸得到了良好的糾正及呼吸功能得到了明顯的增強，同時建立了該類疾病的圍手術(shù)期治療流程。蘇教授十多年來收集了大量遺傳性骨病的標本資源，圍繞骨骼系統(tǒng)畸形和退變性疾病的遺傳發(fā)病機制，開展了從定位基因、構(gòu)建動物模型到功能分析的系列研究，形成了科學的理論體系并運用于臨床優(yōu)生優(yōu)育，同時將精準醫(yī)學理念運用于臨床骨科領(lǐng)域。
研究方向：運動系統(tǒng)發(fā)育畸形與基因調(diào)控
主要教育和工作經(jīng)歷：
1993.09-1998.07 中山醫(yī)科大學 臨床醫(yī)學 學士學位
2000.09-2003.07 中山大學 外科學 碩士學位，導師：黃東生
2005.09-2008.07 中山大學 骨科學 博士學位，導師：劉尚禮
1998.07-2000.08 深圳沙井人民醫(yī)院 住院醫(yī)師
2003.07-2009.12 中山大學附屬第二醫(yī)院 住院醫(yī)師-主治醫(yī)師
2005.07-2005.09 香港中文大學威爾斯親王醫(yī)院 進修臨床醫(yī)師
2009.12-2013.12 中山大學附屬第一醫(yī)院 副教授/副主任醫(yī)師
2011.03-2013.02 美國德州大學西南醫(yī)學研究中心 聯(lián)合博士后培訓
2013.12-至今 中山大學附屬第一醫(yī)院 研究員
2016.12-至今 中山大學附屬第一醫(yī)院 研究員/主任醫(yī)師
2017.12-至今 中山大學附屬第一醫(yī)院 研究員/主任醫(yī)師/教授
社會兼職：
國際脊柱遺傳、發(fā)育和疾病研究協(xié)會（ICSGDD） 委員
國際矯形與創(chuàng)傷外科學會基礎專業(yè)委員會 常務委員
中國康復醫(yī)學會脊柱脊髓基礎研究學組 委員
中華醫(yī)學會骨科學分會基礎學組 委員
中華醫(yī)學會骨科學分會創(chuàng)新與轉(zhuǎn)化學組 委員
廣東醫(yī)學會脊柱外科分會委員兼脊柱畸形學組 副組長
論著：
1.Peiqiang Su，Ruofan Ma, Chunhai Li, Shangli Liu, Dongsheng Huang(*). Pedicle screw fixation of the cervical spine: guidance by computed tomography. Clinical orthopaedics and related research. 2007 Sep;462:99-104.
2.Peiqiang Su（#）, Ru Li(#), Shangli Liu, Yan Zhou, Xinguang Wang, Nilesh Patil, Christopher S. Mow, Justin C. Mason, Dongsheng Huang(*), Yiming Wang(*). Age at onset-dependent presentations of premature hip osteoarthritis, avascular necrosis of the femoral head, or Legg-Calvé-Perthes disease in a single family, consequent upon a p.Gly1170Ser mutation of COL2A1. Arthritis Rheumatism.2008 Jun;58(6):1701-6.
3.Peiqiang Su（#）, Liangming Zhang（#）, Yan Peng, Anjing Liang, Kaili Du, Dongsheng Huang(*). A histological and ultrastructural study of femoral head cartilage in a new type II collagenopathy. International Orthopaedics (SICOT).2010 Dec;34(8):1333-9.
4.Liangming Zhang（#）, Peiqiang Su（#）, Caixia Xu, Junlin Yang, Weihua Yu, Dongsheng Huang(*). Chondrogenic differentiation of human mesenchymal stem cells: a comparison between micromass and pellet culture systems.Biotechnol Lett. 2010 Sep;32(9):1339-46.
5.Caixia Xu, Peiqiang Su, Yingjun Wang, Xiaofeng Chen, Yongchun Meng, Chang Liu, Xinbing Yu, Xuhui Yang, Weihua Yu, Xiuming Zhang, Andy Peng Xiang(*). A novel biomimetic composite scaffold hybridized with mesenchymal stem cells in repair of rat bone defects models. Journal Of Biomedical Materials Research A. 2010 Nov;95(2):495-503.
6.Liangming Zhang, Peiqiang Su（*）, Caixia Xu, Changhua Chen, Anjing Liang, Kaili Du, Yan Peng, Dongsheng Huang(*).Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression. Journal Of Pineal Research.2010 Nov;49(4):364-72
7.Caixia Xu, Peiqiang Su, Xiaofeng Chen, Yongchun Meng, Weihua Yu, Andy Peng Xiang, Yingjun Wang(*). Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissue engineering. Biomaterials. 2011 Feb;32(4):1051-8
8.Yuanyuan Pei, Yiming Wang, Weijun Huang, Bin Hu, Dongsheng Huang, Yan Zhou, Peiqiang Su(*).Novel mutations of EXT1 and EXT2 genes among families and sporadic cases with multiple exostoses. Genetic Testing and Molecular Biomarkers. 2010 Dec;14(6):865-72.
9.Peiqiang Su（#）, Hongke Ding（#）, Dongsheng Huang, Yan Zhou, Weijun Huang, Liangying Zhong, Tim J Vyse, Yiming Wang（*）. A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family. J Med Genet. 2011 May;48(5):312-6.
10.Dongsheng Huang, Kaili Du, Shingxing Zeng, Wenjie Gao, Lingzhi Huang, Peiqiang Su (*). The security analysis of transpedicular screw fixation in the lower cervical spine and a case report. Spine (Phila Pa 1976). 2011 Dec 15;36(26):E1702-8.
11.Peiqiang Su（#）, Wentong Zhang（#）, Yan Peng, Anjing Liang, Kaili Du, Dongsheng Huang（*）. Use of computed tomographic reconstruction to establish the ideal entry point for pedicle screws in idiopathic scoliosis. European Spine Journal. 2012 Jan;21(1):23-30.
12.Yan Peng（#）, Guoyan Liang（#）, Yuanyuan Pei, Wei Ye, Anjing Liang, Peiqiang Su (*). Genomic polymorphisms of G-Protein Estrogen Receptor 1 are associated with severity of adolescent idiopathic scoliosis. International Orthopaedics (SICOT) .2012 Mar;36(3):671-7
13.Guoyan Liang（#）, Wenjie Gao（#）, Anjing Liang, Wei Ye,Yan Peng, Liangming Zhang, Swarkar Sharm, Peiqiang Su (*), Dongsheng Huang（*）.Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to leptin in adolescent idiopathic scoliosis. PLoS One. 2012,7(5): e36648.
14.Liangming Zhang（#）, Jinling Zhang（#）, You Ling, Changhua Chen, Anjing Liang,Yan Peng, Hong Chang, Peiqiang Su (*), Dongsheng Huang（*）. Sustained release of melatonin from poly (lactic-co-glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro. Journal Of Pineal Research. 2013,54:24–32.
15.Wenjie Gao（#）, Yan Peng（#）, Guoyan Liang, Anjing Liang, Wei Ye, Liangming Zhang, Swarkar Sharma, Peiqiang Su(*), Dongsheng Huang（*）. Association between Common Variants near LBX1 and Adolescent Idiopathic Scoliosis Replicated in the Chinese Han Population. PLoS One. 2013, 8(1): e53234.
16.Wenjie Gao（#）, Mianlong Lin（#）, Anjing Liang（#）, Liangming Zhang,Changhua Chen, Guoyan Liang, Caixia Xu, Yan Peng, ChongChen, Dongsheng Huang（*）, Peiqiang Su (*). Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells. Journal Of Pineal Research. 2014, 56(1):62-70.
17.Guoyan Liang（#）, Chengjie Lian（#）, Di Huang, Wenjie Gao, Anjing Liang, Yan Peng, Wei Ye, Zizhao Wu, Peiqiang Su（*）,Dongsheng Huang（*）. Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model. PLoS One. 2014,9(1):e86894.
18.Ye Wang（#）, Peiqiang Su（#）, Bin Hu（#）, Wenjuan Zhu（#）, Qibin Li, Ping Yuan, Jiangchao Li, Xinyuan Guan, Fucheng Li, Xiangyi Jing, Ru Li, Yongling Zhang, Claude Férec, David N. Cooper, Jun Wang, Dongsheng Huang（*）, Jian-Min Chen（*）, Yiming Wang（*）. Characterization of 26 deletion CNVs reveals the frequent occurrence of micro-mutations within the breakpoint-flanking regions and frequent repair of double-strand breaks by templated insertions derived from remote genomic regions. Human Genetics; June 2015, Volume 134, Issue 6, pp 589-603.
19.Peiqiang Su (#), Ye Wang（#）, David N. Cooper, Wenjuan Zhu, Dongsheng Huang, Claude Férec, Yiming Wang, Jian-Min Chen（*）. Disclosing the Hidden Structure and Underlying Mutational Mechanism of a Novel Type of Duplication CNV Responsible for Hereditary Multiple Osteochondromas. Human Mutation; 2015 Aug;36(8):758-63.
20.Chengjie Lian（#）,Zizhao Wu（#）,Bo Gao（#）,Yan Peng,Anjing Liang,Caixia Xu,Lei Liu,XianjianQiu,Junjun Huang,Hang Zhou,Yifeng Cai, Peiqiang Su (*), Dongsheng Huang（*）.Melatonin reversed tumor necrosis factor- alpha- inhibited osteogenesis of human mesenchymal stem cells bystabilizing SMAD1 protein. Journal Of Pineal Research. 2016 Oct;61(3):317-27.
21.Yifeng Cai ,Jiaquan Luo ,Junjun Huang,Chengjie Lian, Hang Zhou,Hao Yao, Peiqiang Su (*).Interspinous spacers versus posterior lumbar interbody fusion for degenerative lumbar spinal diseases: a meta-analysis of prospective studies.International Orthopaedics (SICOT) 2016 Jun;40(6):1135-42
22.Chong Chen（#）, Caixia Xu（#）, Taifeng Zhou, Bo Gao, Hang Zhou, Changhua Chen, Changli Zhang, Dongshen Huang（*）, Peiqiang Su (*). Abnormal osteogenic and chondrogenic differentiation of human mesenchymal stem cells from patients with adolescent idiopathic scoliosis in response to melatonin.Molecular medicine reports. 2016 Aug;14(2):1201-9.
23.Bo Gao, Wenjie Gao, Chong Chen, Qinghua Wang, Shaochun Lin, Caixia Xu, Dongsheng Huang, Peiqiang Su(*)What is the Difference in Morphologic Features of the Thoracic Pedicle Between Patients With Adolescent Idiopathic Scoliosis and Healthy Subjects? A CT-based Case-control Study. Clinical Orthopaedics and Related Research.2017 Nov;475(11):2765-2774.
24.Wenjie Gao（#）, Chong Chen（#）, Taifeng Zhou（#）, Shulan Yang, Bo Gao, Hang Zhou, Chengjie Lian, Zizhao Wu, Xianjian Qiu, Xiaoming Yang, Esam Alattar, Wentao Liu, Deying Su, Silong Sun, Yulan Chen, Kenneth M. C. Cheung, Youqiang Song, Keith K. D. Luk, Danny Chan, Pak Chung Sham, Chao Xing, Chiea Chuen Khor, Gabriel Liu, Junlin Yang, Yubin Deng, Dingjun Hao, Dongsheng Huang, Quan-Zhen Li, Caixia Xu（*）, Peiqiang Su (*).Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis. Human Mutation. 2017 Nov;38(11):1500-1510.
25.Chengjie Lian（#）, Bo Gao（#）, Zizhao Wu, Xianjian Qiu, Yan Peng, Anjing Liang, Caixia Xu（*）, Peiqiang Su (*), Dongsheng Huang.Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells. Mol Med Rep. 2017 Oct;16(4):4730-4736.
26.Kai Han（#）, Yongqian Wang（#）, Shangbin Cui, Caixia Xu（*）, Peiqiang Su (*), Successful surgery for a neuromuscular scoliosis patient by pulmonary rehabilitation with forced vital capacity below 30%. European Spine Journal. 2018 Jan 16.[Epub ahead of print]
27.Taifeng Zhou（#）, Yongqian Wang（#）, Hang Zhou（#）, Zhiheng Liao, Bo Gao, Deying Su, Shuhui Zheng,Caixia Xu(*), Peiqiang Su (*). Dual novel mutations in SLC26A2 in two siblings with multiple epiphyseal dysplasia 4 from a Chinese family: a case report. BMC Medical Genetics. 2018 May 3;19(1):70.
28.Bo Gao（#）, Wenjie Gao（#）, Zizhao Wu（#）, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su (*), Dongsheng Huang(*). Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells. Stem Cell Research & Therapy.2018 Jun 14;9(1):162.
29.Taifeng Zhou（#）,Chong Chen（#）,Caixia Xu（#）,Hang Zhou,Bo Gao,Deying Su,Zhiheng Liao,Yongyong Li,Shulan Yang, Peiqiang Su (*),Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Cellular Physiology and Biochemistry. 2018 Jul 20;48(3):880-890
30.Zizhao Wu（#）, Xianjian Qiu（#）, Bo Gao（#）, Chengjie Lian, Yan Peng, Anjing Liang, Caixia Xu, Wenjie Gao, Liangming Zhang, Peiqiang Su, Limin Rong(*), Dongsheng Huang(*).Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells. Journal Of Pineal Research. 2018 Aug;65(1):e12483.
31.Shuhui Zheng（#），Hang Zhou（#），Zhuohui Chen, Yongyong Li, Taifeng Zhou, Chengjie Lian, Bo Gao, Peiqiang Su（*），Caixia Xu(*). Type III Transforming Growth Factor-β Receptor RNA Interference (RNAi) Enhances TGF-β3-induced Chondrogenesis Signaling in Human Mesenchymal Stem Cells. Stem Cells Internation. 2018; 2018: 4180857.
32.Shuhui Zheng（#），Hang Zhou（#），Bo Gao, YongyongLi, Zhiheng Liao, Taifeng Zhou, Chengjie Lian, Zizhao Wu, Deying Su, Tingting Wang，Peiqiang Su(*)，Caixia Xu(*). Estrogen promotes the onset and development of idiopathic scoliosis via disproportionate endochondral ossification of the anterior and posterior column in a bipedal rat model. Experimental & Molecular Medicine. 2018 Nov; 50(11): 144.
其他主要工作成績（比如獲獎情況）：
1、X基因突變引起特發(fā)性脊柱側(cè)凸的發(fā)生--COA趙以甦骨科基礎獎二等獎 2014年
2、中山大學實習醫(yī)生臨床技能大賽--"教官組"特等獎 2013年
3、股骨頸骨折外科治療的基礎與臨床研究--廣州市科技進步二等獎2008年（第八名）
4、新技術(shù)治療退變性腰椎間盤病的基礎與臨床研究--廣東省科技進步二等獎2006年（第七名）
未知地區(qū)
